5-Aminovaleric acid → Methyl 5-aminopentanoate hydrochloride

HRID 16696

反応式

HRID 16696 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7].S(Cl)([Cl:11])=O.[CH3:13]O>>[ClH:11].[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH3:13])=[O:7]

参加物

4

反応物 3

HCID 1385-Aminovaleric acidHCID 887MethanolHCID 24386Thionyl Chloride

生成物 1

HCID 13672034Methyl 5-aminopentanoate hydrochloride

実験手順

5-Aminovaleric acid (7.35 g) is dissolved in methanol (50 ml), and thereto is added dropwise thionyl chloride (4.9 ml) under ice-cooling. The reaction solution is then warmed to room temperature and stirred for 17 hours. The reaction solution is concentrated under reduced pressure. The resulting residue is suspended in diethyl ether and the precipitates are collected by filtration to give methyl 5-aminovalerate hydrochloride (9.93 g).

後処理

  1. temperaturecooling
  2. concentrationThe reaction solution is concentrated under reduced pressure
  3. filtrationthe precipitates are collected by filtration

出典と根拠

ORDレコード
ord-aa88e5f4b1ca45bfa1e9bb7a8dcca652
出典データセット
uspto-grants-2010_06
特許番号
US07737161B2

関連ノート

読み込み中…