Acetic Acid → N-(2-Oxo-2,3-dihydro-1H-indol-4-yl)glycine

HRID 1669685ノート

反応式

HRID 1669685 の反応式
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[NH:11][CH2:12][C:13]([O:15]CC2C=CC=CC=2)=[O:14])[NH:3]1.CCOC(C)=O.CC(O)=O>CCO.[Pd]>[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[NH:11][CH2:12][C:13]([OH:15])=[O:14])[NH:3]1

参加物

6

反応物 3

HCID 176Acetic AcidHCID 8857Ethyl AcetateHCID 66813100Benzyl N-(2-oxo-2,3-dihydro-1H-indol-4-yl)glycinate

生成物 1

HCID 59322832N-(2-Oxo-2,3-dihydro-1H-indol-4-yl)glycine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 10% Pd/C (100 mg) and benzyl N-(2-oxo-2,3-dihydro-1H-indol-4-yl)glycinate from Step C (320 mg, 1.08 mmol) was stirred vigorously in EtOH (5 mL), EtOAc (5 mL), and AcOH (1 mL) under an atmosphere of hydrogen (ca. 1 atm). After 4 h, the mixture was filtered through a pad of Celite, washing with MeOH, and the filtrate was concentrated to give the title compound. MS: m/z=207 (M+1).

後処理

  1. filtrationthe mixture was filtered through a pad of Celite
  2. washwashing with MeOH
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-a0617c25583c42dcb0e16982a88fa609
出典データセット
uspto-grants-2011_08
特許番号
US07989624B2

反応ノート

読み込み中…