3-Methyl-5-(4-methylphenyl)isoxazole → 3-Amino-1-(4-methylphenyl)but-2-en-1-one

HRID 1669801ノート

反応式

HRID 1669801 の反応式
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[O:4][N:3]=1>[Pt](=O)=O.C(O)C>[NH2:3][C:2]([CH3:1])=[CH:6][C:5]([C:7]1[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][CH:12]=1)=[O:4]

参加物

4

反応物 1

HCID 103521723-Methyl-5-(4-methylphenyl)isoxazole

生成物 1

HCID 673437903-Amino-1-(4-methylphenyl)but-2-en-1-one

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

3-Methyl-5-(4-methylphenyl)isoxazole (1 g, 5.77 mmol) is introduced into 20 ml of ethanol, platinum(IV) oxide catalyst (100 mg) is added, and the mixture is then hydrogenated under atmospheric hydrogen for 12 h. The catalyst is filtered off and the filtrate is concentrated. 1.02 g (100% of theory) of the title compound are obtained as a white solid.

後処理

  1. additionis added
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated

出典と根拠

ORDレコード
ord-27a6cf0c335441e7ac03812465a2a108
出典データセット
uspto-grants-2011_08
特許番号
US07989633B2

反応ノート

読み込み中…