5-(4-Fluorophenyl)-3-methyl-1,2-oxazole → HCID 67342452、化合物
反応式
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[O:4][N:3]=1.[H][H]>[Pt](=O)=O.C(O)C>[NH2:3][C:2]([CH3:1])=[CH:6][C:5]([C:7]1[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=1)=[O:4]参加物
5
実験手順
3-Methyl-5-(4-fluorophenyl)isoxazole (620 mg, 3.49 mmol) is introduced into 16 ml of ethanol, platinum(IV) oxide catalyst (62 mg) is added, and the mixture is then hydrogenated under atmospheric pressure hydrogen for 12 h. The catalyst is filtered off and the filtrate is concentrated. 573 mg (91% of theory) of the title compound are obtained as a white solid.
後処理
- additionis added
- filtrationThe catalyst is filtered off
- concentrationthe filtrate is concentrated
出典と根拠
- ORDレコード
- ord-bc8c514d17cf4445b9a84141324b1a31
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07989633B2
反応ノート
読み込み中…