Lithium Hydroxide → (2R)-N-methanesulfonyl-(4-chlorophenyl)alanine
反応式
C[O:2][C:3](=[O:18])[C@@H:4]([CH3:17])[N:5]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[S:6]([CH3:9])(=[O:8])=[O:7].[Li+].[OH-]>O.CO>[CH3:9][S:6]([N:5]([C:10]1[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=1)[C@@H:4]([C:3]([OH:18])=[O:2])[CH3:17])(=[O:7])=[O:8]参加物
4
実験手順
To a solution of (2R)-N-methanesulfonyl-(4-chlorophenyl)alanine methylester, prepared in Step A, in water/methanol (5 mL, 1/1) was added portionwise LiOH (70.0 mg, 2.00 mmol). After being stirred at rt for 3 h, the reaction mixture was concentrated, and the residue was diluted with 1N HCl solution. The organic material was extracted with EtOAc, the extracts were concentrated in vacuo to give the title compound (179 mg, 94.3%).
後処理
- concentrationthe reaction mixture was concentrated
- additionthe residue was diluted with 1N HCl solution
- extractionThe organic material was extracted with EtOAc
- concentrationthe extracts were concentrated in vacuo
出典と根拠
- ORDレコード
- ord-17e24dfe560444e78f5a74562a9c6df4
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07989634B2
反応ノート
読み込み中…