Sodium Hydroxide → 3-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic Acid

HRID 1670075ノート

反応式

HRID 1670075 の反応式
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[C:6]([C:18]2[CH:26]=[CH:25][C:21]3[O:22][CH2:23][O:24][C:20]=3[CH:19]=2)[CH:5]=1.[OH-].[Na+]>O1CCOCC1>[O:22]1[C:21]2[CH:25]=[CH:26][C:18]([C:6]3[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH2:11][C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)[CH:7]=3)[C:3]([OH:27])=[O:2])=[CH:19][C:20]=2[O:24][CH2:23]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 579059323-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic Acid Methyl Ester

生成物 1

HCID 579058343-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic Acid収率 97%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

3-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic acid methyl ester (14.2 g) was dissolved in 1,4-dioxane (200 mL) and then 1 M aq. NaOH (40 mL) was added. The mixture was stirred at room temperature overnight. The solvents were removed under reduced pressure and the residue was diluted with water (200 mL). It was then made acidic by addition of 10% HCl (aq.) solution and the precipitated material was collected by filtration. The solid was washed with water and dried to yield 13.2 g (97% yield) of the title compound.

後処理

  1. customThe solvents were removed under reduced pressure
  2. additionthe residue was diluted with water (200 mL)
  3. additionmade acidic by addition of 10% HCl (aq.) solution
  4. filtrationthe precipitated material was collected by filtration
  5. washThe solid was washed with water
  6. customdried

出典と根拠

ORDレコード
ord-98aa8d1dc14548ef902dbda8b628317c
出典データセット
uspto-grants-2011_08
特許番号
US07989454B2

反応ノート

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