Succinic Acid → 7-Chloro-6-[2-(cyclopropylmethyl-amino)-thiazol-5-ylthiomethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepine Succinate
反応式
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]2[CH2:6][CH2:7][NH:8][CH2:9][CH2:10][C:4]=2[C:3]=1[CH2:13][S:14][C:15]1[S:19][C:18]([NH:20][CH2:21][CH:22]2[CH2:24][CH2:23]2)=[N:17][CH:16]=1.[C:25]([OH:32])(=[O:31])[CH2:26][CH2:27][C:28]([OH:30])=[O:29]>C(O)C>[C:25]([OH:32])(=[O:31])[CH2:26][CH2:27][C:28]([OH:30])=[O:29].[Cl:1][C:2]1[CH:12]=[CH:11][C:5]2[CH2:6][CH2:7][NH:8][CH2:9][CH2:10][C:4]=2[C:3]=1[CH2:13][S:14][C:15]1[S:19][C:18]([NH:20][CH2:21][CH:22]2[CH2:24][CH2:23]2)=[N:17][CH:16]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
To a solution of 7-chloro-6-[2-(cyclopropylmethyl-amino)-thiazol-5-ylthiomethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepine (0.055 g, 0.144 mmol) in absolute ethanol (5 mL) add succinic acid (0.017 g, 0.144 mmol). After acid dissolves, concentrate the reaction mixture in vacuo. Combine the residue with MTBE, concentrate in vacuo several times and dry under high vacuum at room temperature overnight to obtain the title compound (0.072 g, 100%) as a white foam. MS (ES+) m/z: 380.0 (M+H)+.