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Hydrochloric Acid → Hydroxy-di-thiophen-2-yl-acetic acid (1S,2R,4S,7S)-7-[(9-hydroxy-nonyl)-methyl-amino]-bicyclo[2.2.1]hept-2-yl ester

HRID 1670898
ノート
印刷プレビュー

反応式

HRID 1670898 の反応式
C([Si](C)(C)[O:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][N:16]([CH3:39])[C@H:17]1[C@H:21]2[CH2:22][CH2:23][C@@H:18]1[C@H:19]([O:24][C:25](=[O:38])[C:26]([OH:37])([C:32]1[S:33][CH:34]=[CH:35][CH:36]=1)[C:27]1[S:28][CH:29]=[CH:30][CH:31]=1)[CH2:20]2)(C)(C)C.Cl.C([O-])(O)=O.[Na+]>C1COCC1>[OH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][N:16]([CH3:39])[C@H:17]1[C@H:21]2[CH2:22][CH2:23][C@@H:18]1[C@H:19]([O:24][C:25](=[O:38])[C:26]([OH:37])([C:32]1[S:33][CH:34]=[CH:35][CH:36]=1)[C:27]1[S:28][CH:29]=[CH:30][CH:31]=1)[CH2:20]2
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 67349685Hydroxy-di-thiophen-2-yl-acetic acid (1S,2R,4S,7S)-7-{[9-(tert-butyldimethyl-silanyloxy)nonyl]methylamino}bicyclo[2.2.1]hept-2-ylester

生成物 1

HCID 67349318Hydroxy-di-thiophen-2-yl-acetic acid (1S,2R,4S,7S)-7-[(9-hydroxy-nonyl)-methyl-amino]-bicyclo[2.2.1]hept-2-yl ester

試薬・触媒・溶媒 1

HCID 8028
Tetrahydrofuran
溶媒

実験手順

A solution of hydroxy-di-thiophen-2-yl-acetic acid (1S,2R,4S,7S)-7-{[9-(tert-butyl-dimethyl-silanyloxy)-nonyl]-methyl-amino}-bicyclo[2.2.1]hept-2-yl ester (0.51 g, 0.82 mmol) in THF (7 mL) was treated with 1 M HCl (3.5 mL) and stirred at RT for 45 min. The reaction mixture was neutralised with satd NaHCO3 (aq) and extracted with ethyl acetate. The combined organic layers were dried (Na2SO4), filtered, and concentrated to dryness to afford a light brown oil, which was used without further purification.

後処理

  1. extractionextracted with ethyl acetate
  2. dry with materialThe combined organic layers were dried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated to dryness
  5. customto afford a light brown oil, which
  6. customwas used without further purification

出典と根拠

ORDレコード
ord-84e19e191d474972861914927ea02853
出典データセット
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07994211B2

反応ノート

読み込み中…

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