2-Bromo-1-(4-bromo-2-methylphenyl)propan-1-one → 2-Bromo-1-(2-chloro-4-[1,2,4]triazol-1-yl-phenyl)-butan-1-one

HRID 1671357

反応式

HRID 1671357 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[Br:16][CH:17](C)[C:18]([C:20]1C=CC(Br)=CC=1C)=O.C([Mg]Br)C>>[Br:16][CH:17]([CH2:18][CH3:20])[C:4]([C:3]1[CH:7]=[CH:8][C:9]([N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)=[CH:10][C:2]=1[Cl:1])=[O:6]

参加物

4

反応物 3

HCID 185201832-Bromo-1-(4-bromo-2-methylphenyl)propan-1-oneHCID 187950272-Chloro-4-(1H-1,2,4-triazol-1-yl)-benzenecarboxylic acidHCID 178418443HCID 178418443、化合物

生成物 1

HCID 866389422-Bromo-1-(2-chloro-4-[1,2,4]triazol-1-yl-phenyl)-butan-1-one

実験手順

This compound is prepared from 2-chloro-4-[1,2,4]triazol-1-yl-benzoic acid analgously to 2-bromo-1-(4-bromo-2-methyl-phenyl)-propan-1-one (Intermediate MA) by replacing ethylmagnesium bromide with the appropriate alkyl magnesium bromide.

出典と根拠

ORDレコード
ord-6ab47deff1b24250acf9d92a02d111fe
出典データセット
uspto-grants-2011_08
特許番号
US07994203B2

関連ノート

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