Sodium Hydroxide → (S)-(4-Fluorophenyl)oxirane
反応式
[OH-].[Na+].Cl[CH2:4][C@H:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[OH:6]>C(OCC)C>[F:13][C:10]1[CH:11]=[CH:12][C:7]([C@H:5]2[CH2:4][O:6]2)=[CH:8][CH:9]=1参加物
4
実験手順
1.6 M aqueous sodium hydroxide solution (50 ml) was added to a solution of 2-chloro-(1S)-1-(4-fluorophenyl)ethanol (10.4 g) in diethyl ether (40 ml), and the mixture was stirred at room temperature for 5 hrs. The organic layer was separated and the aqueous layer was extracted with diethyl ether. The combined organic layer was washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give (2S)-2-(4-fluorophenyl)oxirane (8.28 g) as a colorless oil.
後処理
- customThe organic layer was separated
- extractionthe aqueous layer was extracted with diethyl ether
- washThe combined organic layer was washed with brine
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-a2c1a25bbfbd460b93acd43a194b2fd2
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07994315B2
反応ノート
読み込み中…