Water → Ethyl orotate
反応式
O.[C:2]([OH:12])(=[O:11])[C:3]1[NH:10][C:8](=[O:9])[NH:7][C:5](=[O:6])[CH:4]=1.N12CCCN=C1CCC[CH2:15][CH2:14]2.C(I)C.O>CN(C)C=O>[C:2]([O:12][CH2:14][CH3:15])(=[O:11])[C:3]1[NH:10][C:8](=[O:9])[NH:7][C:5](=[O:6])[CH:4]=1参加物
6
反応条件
- 温度
- 60 °C
実験手順
Orotic acid monohydrate (53.19 g, 0.306 mmol) was added to a solution of 1,8-diazabicyclo[5.4.0]undec-7-ene (46.51 g, 0.306 mmol) in dimethylformamide (85 ml). After stirring for 5 min., ethyl iodide (57.14 g, 0.366 mmol) was added to the solution and the mixture was heated at 60° C. for 5 hrs. Water (1 L) was added, and the resulting precipitate was collected by filtration, washed with water, and dried to give ethyl orotate (49.25 g, 88%).
後処理
- filtrationthe resulting precipitate was collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-192370183dd54a67b7d60c20efe49261
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07994315B2
反応ノート
読み込み中…