Methyl 2-fluoro-4-nitrobenzoate → Methyl 4-amino-2-fluorobenzoate

HRID 1671661ノート

反応式

HRID 1671661 の反応式
[F:1][C:2]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[H][H]>CO.O1CCCC1.[Ni]>[NH2:12][C:10]1[CH:9]=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([F:1])[CH:11]=1

参加物

6

反応物 2

HCID 3013872Methyl 2-fluoro-4-nitrobenzoateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 21957875Methyl 4-amino-2-fluorobenzoate

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl 2-fluoro-4-nitrobenzoate (141 mg) was dissolved in methanol (1000 ml) and tetrahydrofuran (400 ml), and Raney nickel (20 g) was added to it, and stirred overnight in a hydrogen atmosphere. The catalyst was removed through filtration, and the solvent was evaporated away under reduced pressure to obtain methyl 4-amino-2-fluorobenzoate.

後処理

  1. customThe catalyst was removed through filtration
  2. customthe solvent was evaporated away under reduced pressure

出典と根拠

ORDレコード
ord-a0566c2eb2894387b636427eeefdb2ad
出典データセット
uspto-grants-2011_08
特許番号
US07994331B2

反応ノート

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