(2-Bromo-4-fluorobenzo[d]thiazol-6-yl)methanol → 2-Bromo-4-fluorobenzo[d]thiazole-6-carbaldehyde
反応式
[Br:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH2:11][OH:12])[CH:8]=[C:7]([F:13])[C:5]=2[N:6]=1>C1COCC1.[O-2].[Mn+4].[O-2]>[Br:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH:11]=[O:12])[CH:8]=[C:7]([F:13])[C:5]=2[N:6]=1参加物
4
実験手順
A mixture of (2-bromo-4-fluorobenzo[d]thiazol-6-yl)methanol (0.269 g, 1.03 mmol) and manganese (IV) oxide (activated, 85%, 1.47 g, 14.4 mmol) in THF (15 mL) was stirred at rt for 16 hr. Solid material was removed by filtration through Celite® 545, and the filtrate was concentrated under vacuum. The residue was diluted with AcOEt, washed with brine, and dried over anhydrous MgSO4. Evaporation of solvent under vacuum gave the title compound (0.136 g, 61% yield) as a white solid.
後処理
- customSolid material was removed by filtration through Celite® 545
- concentrationthe filtrate was concentrated under vacuum
- additionThe residue was diluted with AcOEt
- washwashed with brine
- dry with materialdried over anhydrous MgSO4
- customEvaporation of solvent under vacuum
出典と根拠
- ORDレコード
- ord-862a1e110bbb4c739561a733cac3a0b1
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07994337B2
反応ノート
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