Hydrochloric Acid → 4-Hydroxy-2-methoxybenzoic acid
反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1.O.O[Li].O.Cl>C1COCC1>[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1参加物
6
実験手順
To a stirred solution of methyl 4-hydroxy-2-methoxybenzoate (11 g, 60 mmol) in THF:H2O (100 mL:10 mL) was added LiOH.H2O (3 g, 71 mmol). The solution was stirred over 24 h and then made slightly acidic (pH 5) with 10% HCl (approx 15 mL). The reaction solution was extracted with CH2Cl2 (3×50 mL). The organic phase was dried (MgSO4) and filtered. The solvent was evaporated under reduced pressure to afford the 4-hydroxy-2-methoxybenzoic acid as a clean white foam.
後処理
- extractionThe reaction solution was extracted with CH2Cl2 (3×50 mL)
- dry with materialThe organic phase was dried (MgSO4)
- filtrationfiltered
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-c1656a56b0b84177904d3a04b5264874
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05726172
反応ノート
読み込み中…