Hydrochloric Acid → 1-(Pyridazin-3-yl)cyclopropanamine hydrochloride
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([NH:10]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)[N:2]=1.[ClH:18]>C1COCC1.O1CCOCC1>[ClH:18].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([NH2:10])[CH2:9][CH2:8]2)[N:2]=1参加物
5
実験手順
To a solution of tert-butyl 1-(pyridazin-3-yl)cyclopropylcarbamate (0.3 g) in THF (3 ml) at 0° C. was added HCl in dioxane (5 ml) and the mixture stirred at r.t. for 3 hr. The reaction mixture was concentrated, and the crude product was taken for the next coupling reaction. Yield: 0.21 g
後処理
- concentrationThe reaction mixture was concentrated
- customthe crude product was taken for the next coupling reaction
出典と根拠
- ORDレコード
- ord-3698dbfaf96048ed8a02bcd7e3d7795e
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07994171B2
反応ノート
読み込み中…