8-vinyl-3,4-dihydro-1H-1-benzazepine-2,5-dione → 8-ethyl-3,4-dihydro-1H-1-benzazepine-2,5-dione
反応式
[CH:1]([C:3]1[CH:15]=[CH:14][C:6]2[C:7](=[O:13])[CH2:8][CH2:9][C:10](=[O:12])[NH:11][C:5]=2[CH:4]=1)=[CH2:2]>CCO.[Pd]>[CH2:1]([C:3]1[CH:15]=[CH:14][C:6]2[C:7](=[O:13])[CH2:8][CH2:9][C:10](=[O:12])[NH:11][C:5]=2[CH:4]=1)[CH3:2]参加物
4
反応条件
- 温度
- 70 °C
実験手順
To a solution of 8-vinyl-3,4-dihydro-1H-1-benzazepine-2,5-dione (2.6 g, 13 mmol) in EtOH (160 mL) was added 10% (w/w) palladium on carbon (260 mg). The reaction mixture was allowed to stir under an atmosphere of H2 (5 bar) at 70° C. until reaction was complete. The reaction mixture was filtered over Celite® and the filtrate was concentrated to give 8-ethyl-3,4-dihydro-1H-1-benzazepine-2,5-dione (2.4 g, 91%),
後処理
- filtrationThe reaction mixture was filtered over Celite®
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-0ed6351f710f427d80ec489bcb65fb17
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07998952B2
反応ノート
読み込み中…