Isobutyraldehyde → 7-(2-Chlorophenyl)-1-isobutyl-1,7-diazaspiro[4.4]nonan-6-one

HRID 1672378ノート

反応式

HRID 1672378 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:16][CH2:15][C:10]2([NH:14][CH2:13][CH2:12][CH2:11]2)[C:9]1=[O:17].[CH:18](=O)[CH:19]([CH3:21])[CH3:20].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:16][CH2:15][C:10]2([N:14]([CH2:18][CH:19]([CH3:21])[CH3:20])[CH2:13][CH2:12][CH2:11]2)[C:9]1=[O:17]

参加物

5

反応物 3

HCID 6561IsobutyraldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 589483317-(2-Chlorophenyl)-1,7-diazaspiro[4.4]nonan-6-one

生成物 1

HCID 166550297-(2-Chlorophenyl)-1-isobutyl-1,7-diazaspiro[4.4]nonan-6-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

7-(2-Chlorophenyl)-1,7-diazaspiro[4.4]nonan-6-one (20 mg, 0.00008 mol) was dissolved in anhydrous DCM (2 mL). To this mixture was added isobutyraldehyde (8.0 μL, 0.000088 mol) and sodium triacetoxyborohydride (3.0E1 mg, 0.00014 mol). The resulting solution was stirred at RT for 16 h. The volatiles were removed in vacuo and the resulting residue was dissolved in acetonitrile/H2O and purified by prep.-LC/MS chromatography to afford the desired product. LC-MS: 307.1 (M+1H)+.

後処理

  1. customThe volatiles were removed in vacuo
  2. dissolutionthe resulting residue was dissolved in acetonitrile/H2O
  3. custompurified by prep.-LC/MS chromatography

出典と根拠

ORDレコード
ord-8c5223cd1979476598927ad65121b715
出典データセット
uspto-grants-2011_08
特許番号
US07998959B2

反応ノート

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