Hydrochloric Acid → 3-Hydroxy-4-methyl-2-nitrobenzoic acid

HRID 1672477

反応式

HRID 1672477 の反応式
C(N[C:5]1[C:6]([N+:15]([O-:17])=[O:16])=[C:7]([CH:11]=[CH:12][C:13]=1[CH3:14])[C:8]([OH:10])=[O:9])(=O)C.[OH-:18].[K+].Cl>O>[OH:18][C:5]1[C:6]([N+:15]([O-:17])=[O:16])=[C:7]([CH:11]=[CH:12][C:13]=1[CH3:14])[C:8]([OH:10])=[O:9]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 2434333-Acetamido-4-methyl-2-nitrobenzoic acid

生成物 1

HCID 813743-Hydroxy-4-methyl-2-nitrobenzoic acid収率 93.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 3-(acetylamino)-4-methyl-2-nitrobenzoic acid (237.5 g, 0.997 mol) and KOH (451.2 g, 8.04 mol) in water (2830 mL) was refluxed for 48 h. The dark red solution was cooled and acidified to pH 1 with concentrated HCl. The yellow solid was filtered and re-crystallized from water (1800 mL) to give the title compound (183 g, 93.4%) as a yellow solid.

後処理

  1. temperatureThe dark red solution was cooled
  2. filtrationThe yellow solid was filtered
  3. customre-crystallized from water (1800 mL)

出典と根拠

ORDレコード
ord-38c31f1419744cd699942a50b6d9a0af
出典データセット
uspto-grants-2011_08
特許番号
US07998978B2

関連ノート

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