[2-(5-Phenylpentyloxy)phenyl]methanol → Triphenyl[2-(5-phenylpentyloxy)benzyl]phosphonium bromide

HRID 1672629

反応式

HRID 1672629 の反応式
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH2:19]O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BrH:21].[C:22]1([PH+:28]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(#N)C>[Br-:21].[C:35]1([P+:28]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:19][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[O:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

参加物

4

反応物 2

HCID 20764199[2-(5-Phenylpentyloxy)phenyl]methanolHCID 22178555Triphenylphosphonium hydrobromide

生成物 1

HCID 22560990Triphenyl[2-(5-phenylpentyloxy)benzyl]phosphonium bromide収率 93.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 18.7 g (69.16 mmol) of [2-(5-phenylpentyloxy)phenyl]methanol from Example 27A in 120 ml of acetonitrile is mixed with 22.55 g (65.71 mmol) of triphenylphosphonium hydrobromide and heated to reflux for three hours. The reaction solution is then concentrated to dryness. 36.6 g (61.45 mmol, 83% yield) of crystalline product are obtained and are reacted without further purification.

後処理

  1. temperatureheated
  2. temperatureto reflux for three hours
  3. concentrationThe reaction solution is then concentrated to dryness

出典と根拠

ORDレコード
ord-048e4ae8aa1e4349bdcd5635f748593f
出典データセット
uspto-grants-2011_08
特許番号
US07998988B2

関連ノート

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