Pyridine → HCID 19170012、化合物
反応式
[I:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:6][NH2:7])=[O:5].N1C=CC=CC=1.[C:18](Cl)(=[O:20])[CH3:19]>ClCCl>[C:18]([NH:7][NH:6][C:4](=[O:5])[C:3]1[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=1[I:1])(=[O:20])[CH3:19]参加物
5
反応条件
- 温度
- 0 °C
実験手順
2-Iodobenzohydrazide (1.38 g, 5.27 mmol) obtained in Step 1 of Example 114 was dissolved in dichloromethane (50 mL), and the mixture was stirred at 0° C. for 1.5 hours after adding pyridine (0.639 mL, 7.90 mmol) and acetyl chloride (0.412 mL, 5.79 mmol). The precipitated solid was filtered off, and the resulting solid was dried under reduced pressure to give N′-acetyl-2-iodobenzohydrazide (1.23 g, 77%).
後処理
- filtrationThe precipitated solid was filtered off
- customthe resulting solid was dried under reduced pressure
出典と根拠
- ORDレコード
- ord-964784db775d4e29a25e91b4cee09636
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07998954B2
反応ノート
読み込み中…