Water → 5-(3-iodophenyl)-3-methyl-1,3,4-oxadiazol-2 (3H)-one

HRID 1672847ノート

反応式

HRID 1672847 の反応式
[I:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11](=[O:13])[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:14](=O)([O-])[O-].[K+].[K+].CI.O>CN(C=O)C>[I:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11](=[O:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 21071758HCID 21071758、化合物

生成物 1

HCID 673486545-(3-iodophenyl)-3-methyl-1,3,4-oxadiazol-2 (3H)-one収率 90.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

5-(3-Iodophenyl)-1,3,4-oxadiazol-2(3H)-one (778 mg, 2.70 mmol) obtained in Step 1 was dissolved in DMF (14 mL), and the mixture was stirred at room temperature for 1 hour after adding potassium carbonate (840 mg, 4.05 mmol) and methyl iodide (0.20 mL, 3.24 mmol). The mixture was stirred after adding water, and the precipitated solid was filtered off and dried to give 5-(3-iodophenyl)-3-methyl-1,3,4-oxadiazol-2 (3H)-one (736 mg, 90%).

後処理

  1. stirringThe mixture was stirred
  2. filtrationthe precipitated solid was filtered off
  3. customdried

出典と根拠

ORDレコード
ord-ea7a6f97ad6f4354a0d3e8fbb083e0ae
出典データセット
uspto-grants-2011_08
特許番号
US07998954B2

反応ノート

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