Trifluoroacetic acid → HCID 59715655、化合物

HRID 1673098ノート

反応式

HRID 1673098 の反応式
FC(F)(F)C(O)=O.[CH2:8]([C:12]1[CH:28]=[CH:27][C:15]([CH2:16][C:17]2[C:22]([O:23]COC)=[CH:21][CH:20]=[CH:19][N:18]=2)=[CH:14][CH:13]=1)[CH2:9][CH2:10][CH3:11].C(=O)([O-])O.[Na+].C(OCC)(=O)C>C(Cl)Cl>[CH2:8]([C:12]1[CH:28]=[CH:27][C:15]([CH2:16][C:17]2[C:22]([OH:23])=[CH:21][CH:20]=[CH:19][N:18]=2)=[CH:14][CH:13]=1)[CH2:9][CH2:10][CH3:11]

参加物

6

反応物 4

HCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 516892Sodium BicarbonateHCID 57712181HCID 57712181、化合物

生成物 1

HCID 59715655HCID 59715655、化合物収率 88.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (1 ml) was added to a solution of the compound of Example B229 (256 mg, 0.849 mmol) in methylene chloride (5 ml), and this reaction mixture was stirred at room temperature overnight. After a saturated aqueous sodium hydrogencarbonate solution and ethyl acetate were added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (182 mg).

後処理

  1. washthe reaction mixture was washed with saturated brine
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-210ca8d97b0f456d9f7432cc5c07b96f
出典データセット
uspto-grants-2011_08
特許番号
US07999090B2

反応ノート

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