Tert-butyl 4-(2,4-difluorophenyl)-2-(4-fluorobenzamido)benzoate → 4-(2,4-Difluorophenyl)-2-(4-fluorobenzamido)benzoic acid
反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:21]=[CH:20][C:12]([C:13]([O:15]C(C)(C)C)=[O:14])=[C:11]([NH:22][C:23](=[O:31])[C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[CH:10]=1>FC(F)(F)C(O)=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:21]=[CH:20][C:12]([C:13]([OH:15])=[O:14])=[C:11]([NH:22][C:23](=[O:31])[C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[CH:10]=1参加物
3
実験手順
10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-(2,4-difluorophenyl)-2-(4-fluorobenzamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 46 mg of 4-(2,4-difluorophenyl)-2-(4-fluorobenzamido)benzoic acid as white solid.
後処理
- customThe solvent was evaporated under reduced pressure and diisopropyl ether