Tert-butyl 2-(2,3-dimethylbenzamido)-4-(4-(tert-butoxycarbonyl)oxyphenyl)benzoate → 2-(2,3-Dimethylbenzamido)-4-(4-hydroxyphenyl)benzoic acid

HRID 1673442ノート

反応式

HRID 1673442 の反応式
[CH3:1][C:2]1[C:37]([CH3:38])=[CH:36][CH:35]=[CH:34][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][C:23]([O:26]C(OC(C)(C)C)=O)=[CH:22][CH:21]=2)[CH:17]=[CH:16][C:8]=1[C:9]([O:11]C(C)(C)C)=[O:10])=[O:5]>FC(F)(F)C(O)=O>[CH3:1][C:2]1[C:37]([CH3:38])=[CH:36][CH:35]=[CH:34][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=2)[CH:17]=[CH:16][C:8]=1[C:9]([OH:11])=[O:10])=[O:5]

参加物

3

反応物 1

HCID 67342726Tert-butyl 2-(2,3-dimethylbenzamido)-4-(4-(tert-butoxycarbonyl)oxyphenyl)benzoate

生成物 1

HCID 578794792-(2,3-Dimethylbenzamido)-4-(4-hydroxyphenyl)benzoic acid

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2,3-dimethylbenzamido)-4-(4-(tert-butoxycarbonyl)oxyphenyl)benzoate and stirred ah room temperature for 2 hours. The solvent was evaporated under reduced pressure and ethyl acetate was added to the obtained residue and a solid substance was separated by filtration to obtain 20 mg of 2-(2,3-dimethylbenzamido)-4-(4-hydroxyphenyl)benzoic acid as white solid.

後処理

  1. customThe solvent was evaporated under reduced pressure and ethyl acetate
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

出典と根拠

ORDレコード
ord-a30d5ffaa6034487adc5abfb425a26eb
出典データセット
uspto-grants-2011_08
特許番号
US07999132B2

反応ノート

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