Tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoate → 4-(Benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoic acid

HRID 1673444

反応式

HRID 1673444 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:22]=[CH:21][C:13]([C:14]([O:16]C(C)(C)C)=[O:15])=[C:12]([NH:23][C:24](=[O:33])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=4[CH3:32])[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1>FC(F)(F)C(O)=O>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:22]=[CH:21][C:13]([C:14]([OH:16])=[O:15])=[C:12]([NH:23][C:24](=[O:33])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=4[CH3:32])[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

参加物

3

反応物 1

HCID 67342913Tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoate

生成物 1

HCID 578794104-(Benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoic acid

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 31 mg of 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoic acid as white solid.

後処理

  1. customThe solvent was evaporated under reduced pressure and methanol
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

出典と根拠

ORDレコード
ord-9aa7eda3a966471e8efde12db1382b51
出典データセット
uspto-grants-2011_08
特許番号
US07999132B2

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