Tert-butyl 4-(2,4-difluorophenyl)-2-(2,3-dimethylbenzamido)benzoate → 4-(2,4-Difluorophenyl)-2-(2,3-dimethylbenzamido)benzoic acid
反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:21]=[CH:20][C:12]([C:13]([O:15]C(C)(C)C)=[O:14])=[C:11]([NH:22][C:23](=[O:32])[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[C:25]=2[CH3:31])[CH:10]=1>FC(F)(F)C(O)=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:21]=[CH:20][C:12]([C:13]([OH:15])=[O:14])=[C:11]([NH:22][C:23](=[O:32])[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[C:25]=2[CH3:31])[CH:10]=1参加物
3
実験手順
10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-(2,4-difluorophenyl)-2-(2,3-dimethylbenzamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 17 mg of 4-(2,4-difluorophenyl)-2-(2,3-dimethylbenzamido)benzoic acid as white solid. 1H-NMR (DMSO-d6) δ: 2.31 (3H, s), 2.31 (3H, s), 7.21-7.30 (2H, m), 7.31-7.49 (4H, m), 7.63-7.70 (1H, m), 8.11 (1H, d, J=8.0 Hz), 8.89 (1H, s), 11.58 (1H, s).