Tert-butyl 2-(benzamido)-4-(2-chloro-6-fluorophenyl)benzoate → 2-(Benzamido)-4-(2-chloro-6-fluorophenyl)benzoic acid

HRID 1673473ノート

反応式

HRID 1673473 の反応式
[C:1]([NH:9][C:10]1[CH:22]=[C:21]([C:23]2[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=2[Cl:30])[CH:20]=[CH:19][C:11]=1[C:12]([O:14]C(C)(C)C)=[O:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[C:1]([NH:9][C:10]1[CH:22]=[C:21]([C:23]2[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=2[Cl:30])[CH:20]=[CH:19][C:11]=1[C:12]([OH:14])=[O:13])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 67342982Tert-butyl 2-(benzamido)-4-(2-chloro-6-fluorophenyl)benzoate

生成物 1

HCID 578795122-(Benzamido)-4-(2-chloro-6-fluorophenyl)benzoic acid

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(2-chloro-6-fluorophenyl)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and toluene was added. The solvent was evaporated under reduced pressure and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 70-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to obtain 5.8 mg of 2-(benzamido)-4-(2-chloro-6-fluorophenyl)benzoic acid as white solid.

後処理

  1. customThe solvent was evaporated under reduced pressure and toluene
  2. additionwas added
  3. customThe solvent was evaporated under reduced pressure
  4. customthe obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 70-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution]

出典と根拠

ORDレコード
ord-b7cd85a1066e4ee1867658f8ab1af0c9
出典データセット
uspto-grants-2011_08
特許番号
US07999132B2

反応ノート

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