Tert-butyl 2-(2-acetoxybenzamido)-4-phenethylbenzoate → 2-(2-Hydroxybenzamido)-4-phenethylbenzoic acid

HRID 1673530ノート

反応式

HRID 1673530 の反応式
C([O:4][C:5]1[CH:34]=[CH:33][CH:32]=[CH:31][C:6]=1[C:7]([NH:9][C:10]1[CH:22]=[C:21]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:20]=[CH:19][C:11]=1[C:12]([O:14]C(C)(C)C)=[O:13])=[O:8])(=O)C>FC(F)(F)C(O)=O>[OH:4][C:5]1[CH:34]=[CH:33][CH:32]=[CH:31][C:6]=1[C:7]([NH:9][C:10]1[CH:22]=[C:21]([CH2:23][CH2:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:20]=[CH:19][C:11]=1[C:12]([OH:14])=[O:13])=[O:8]

参加物

3

反応物 1

HCID 67341697Tert-butyl 2-(2-acetoxybenzamido)-4-phenethylbenzoate

生成物 1

HCID 578793222-(2-Hydroxybenzamido)-4-phenethylbenzoic acid

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2-acetoxybenzamido)-4-phenethylbenzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and 0.50 mL of methanol, 0.50 mL of tetrahydrofuran and 10 mg of potassium carbonate were added to the obtained residue sequentially and stirred at room temperature for 3 hours. After insoluble were removed by filtration, 3.0 mL of 10% citric acid aqueous solution was added and a solid; substance was separated, by filtration to obtain 11 mg of 2-(2-hydroxybenzamido)-4-phenethylbenzoic acid as white solid.

後処理

  1. customThe solvent was evaporated under reduced pressure and 0.50 mL of methanol, 0.50 mL of tetrahydrofuran and 10 mg of potassium carbonate
  2. additionwere added to the obtained residue sequentially
  3. stirringstirred at room temperature for 3 hours
  4. customAfter insoluble were removed by filtration, 3.0 mL of 10% citric acid aqueous solution
  5. additionwas added
  6. customsubstance was separated, by filtration

出典と根拠

ORDレコード
ord-c6074efba396494aa2dde26bd6388a96
出典データセット
uspto-grants-2011_08
特許番号
US07999132B2

反応ノート

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