1-(3-(Bromomethyl)phenyl)ethan-1-one → Ethyl 2-(3-acetylbenzyl)-3-oxobutanoate

HRID 1673605ノート

反応式

HRID 1673605 の反応式
[C:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7]Br)(=[O:3])[CH3:2].[Na].[C:13]([O:19][CH2:20][CH3:21])(=[O:18])[CH2:14][C:15]([CH3:17])=[O:16]>O1CCCC1>[C:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][CH:14]([C:15](=[O:16])[CH3:17])[C:13]([O:19][CH2:20][CH3:21])=[O:18])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 154798071-(3-(Bromomethyl)phenyl)ethan-1-oneHCID 87089461Ethyl acetoacetatesodium salt

生成物 1

HCID 57460081Ethyl 2-(3-acetylbenzyl)-3-oxobutanoate収率 49.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 3-acetylbenzyl bromide (4 g) and ethyl acetoacetate sodium salt (3.42 g) in tetrahydrofuran (50 mL) was stirred for 12 hr. The insoluble material was filtered off and the filtrate was concentrated. The residue was purified by silica gel column chromatography to give the title compound (2.42 g, 49%) as a colorless viscous oil.

後処理

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-80deb4ce116f4a2ca83522051f2b0db0
出典データセット
uspto-grants-2011_08
特許番号
US07998968B2

反応ノート

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