Water → 5-Bromo-2-chloro-4-(methylthio)pyrimidine
反応式
C(S)[CH2:2][S:3]([O-])(=O)=O.[Na+].[Br:9][C:10]1[C:11](Cl)=[N:12][C:13]([Cl:16])=[N:14][CH:15]=1.O>C(#N)C>[Br:9][C:10]1[C:11]([S:3][CH3:2])=[N:12][C:13]([Cl:16])=[N:14][CH:15]=1参加物
5
実験手順
2 g of MeSNa (28.5 mmol; 1 eq.) and 6.5 g of 5-bromo-2,4-dichloropyrimidine (28.5 mmol, 1 eq.) were stirred in 50 mL dry acetonitrile at rt for 24 h. Then the mixture was poured into water, extracted with DCM, dried (Na2SO4) and evaporated to dryness. The product was recrystallized from hexane to yield 4 g of Intermediate 12 (70% yield).
後処理
- extractionextracted with DCM
- dry with materialdried (Na2SO4)
- customevaporated to dryness
- customThe product was recrystallized from hexane
出典と根拠
- ORDレコード
- ord-8771832bb2d54727880b4c4f54ed2595
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US08003655B2
反応ノート
読み込み中…