benzyl 4-(4-hydroxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylate → 4-Piperidin-4-ylphenol
反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][N:11](C(OCC3C=CC=CC=3)=O)[CH2:10][CH:9]=2)=[CH:4][CH:3]=1>[Pd].CO>[NH:11]1[CH2:12][CH2:13][CH:8]([C:5]2[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=2)[CH2:9][CH2:10]1参加物
4
実験手順
Benzyl 4-(4-hydroxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylate (37.7 g, 121.86 mmol) and 5% palladium on carbon (7.6 g, 3.57 mmol) in methanol (380 mL) were stirred under an atmosphere of hydrogen at 5 bar and 25° C. for 2 hours. The catalyst was removed by filtration, washed with MeOH and the solvents evaporated. The crude material was triturated with diethyl ether, then the desired product collected by filtration and dried under vacuum to afford 4-(piperidin-4-yl)phenol (20.36 g, 94%) as a solid.
後処理
- customThe catalyst was removed by filtration
- washwashed with MeOH
- customthe solvents evaporated
- customThe crude material was triturated with diethyl ether
- filtrationthe desired product collected by filtration
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-6c054b9f826644bf82a98a7b90a4a23a
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US08003649B2
反応ノート
読み込み中…