Hydrochloric Acid → 3,5-Dimethoxy-4-[(prop-2-yn-1-yl)oxy]benzoic acid

HRID 1675567ノート

反応式

HRID 1675567 の反応式
[CH2:1]([O:4][C:5]1[C:16]([O:17][CH3:18])=[CH:15][C:8]([C:9]([O:11]CC#C)=[O:10])=[CH:7][C:6]=1[O:19][CH3:20])[C:2]#[CH:3].[OH-].[Na+].Cl>CO>[CH2:1]([O:4][C:5]1[C:6]([O:19][CH3:20])=[CH:7][C:8]([C:9]([OH:11])=[O:10])=[CH:15][C:16]=1[O:17][CH3:18])[C:2]#[CH:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 593017922-Propynyl 4-(2-propynyloxy)-3,5-dimethoxybenzoate

生成物 1

HCID 131214813,5-Dimethoxy-4-[(prop-2-yn-1-yl)oxy]benzoic acid収率 97.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

To 50 ml of methanol were added 15.5 g of 2-propynyl 4-(2-propynyloxy)-3,5-dimethoxybenzoate and 40 ml of a 15% aqueous sodium hydroxide solution, and the resulting mixture was stirred at 50° C. for 4 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was made acidic by addition of hydrochloric acid. The precipitated crystals were collected by filtration, and dried, and 13.0 g of 4-(2-propynyloxy)-3,5-dimethoxybenzoic acid was obtained.

後処理

  1. temperatureto cool to near room temperature
  2. filtrationThe precipitated crystals were collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-90fc2e508923459780678596902922f9
出典データセット
uspto-grants-2011_08
特許番号
US08003699B2

反応ノート

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