Hydrochloric Acid → 3-Methoxy-4-(prop-2-ynyloxy)benzoic acid

HRID 1675570ノート

反応式

HRID 1675570 の反応式
[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([O:11]CC#C)=[O:10])=[CH:7][C:6]=1[O:17][CH3:18])[C:2]#[CH:3].[OH-].[Na+].Cl>CO>[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1[O:17][CH3:18])[C:2]#[CH:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 593017652-Propynyl 4-(2-propynyloxy)-3-methoxybenzoate

生成物 1

HCID 131214803-Methoxy-4-(prop-2-ynyloxy)benzoic acid収率 107.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 50 ml of methanol were added 13.2 g of 2-propynyl 4-(2-propynyloxy)-3-methoxybenzoate and 40 ml of a 15% aqueous sodium hydroxide solution, and the resulting mixture was stirred at room temperature for 8 hours, and then at 50° C. for 2 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was added to hydrochloric acid to make the mixture acidic. The precipitated crystals were collected by filtration, and dried, and 12.0 g of 4-(2-propynyloxy)-3-methoxybenzoic acid was obtained.

後処理

  1. waitat 50° C. for 2 hours
  2. temperatureto cool to near room temperature
  3. filtrationThe precipitated crystals were collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-dadb5c4102d040e59fa5bc8703307617
出典データセット
uspto-grants-2011_08
特許番号
US08003699B2

反応ノート

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