Toluene → 3,5-Difluoro-4-(2-propynyloxy)benzoyl chloride

HRID 1675582

反応式

HRID 1675582 の反応式
C1(C)C=CC=CC=1.[F:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([F:22])[C:17]=1[O:18][CH2:19][C:20]#[CH:21])[C:12](O)=[O:13].S(Cl)([Cl:25])=O>CN(C=O)C>[F:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([F:22])[C:17]=1[O:18][CH2:19][C:20]#[CH:21])[C:12]([Cl:25])=[O:13]

参加物

5

反応物 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 574456663,5-Difluoro-4-(2-propynyloxy)benzoic acid

生成物 1

HCID 574456963,5-Difluoro-4-(2-propynyloxy)benzoyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To 17 ml of toluene were added 1.8 g of 3,5-difluoro-4-(2-propynyloxy)benzoic acid, 1 ml of thionyl chloride and 10 mg of DMF, and the resulting mixture was heated to reflux for 4 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was concentrated under reduced pressure, and 1.9 g of 3,5-difluoro-4-(2-propynyloxy)benzoyl chloride was obtained.

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureto reflux for 4 hours
  3. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-e11feb2091de4fb0a8761b24f77eb2ec
出典データセット
uspto-grants-2011_08
特許番号
US08003699B2

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