Methyl 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate → Potassium 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate

HRID 1675891ノート

反応式

HRID 1675891 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:13][NH:14][CH2:15][C:16]([F:19])([F:18])[F:17])[C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.O([Si](C)(C)C)[K:21]>C1COCC1.CCOCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH2:13][NH:14][CH2:15][C:16]([F:17])([F:18])[F:19])[C:9]([O-:11])=[O:10])=[CH:6][CH:7]=1.[K+:21]

参加物

5

反応物 2

HCID 66617993Methyl 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoateHCID 178504318HCID 178504318、化合物

生成物 1

HCID 66617976Potassium 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate収率 118%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of methyl 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate (235 mg, 0.795 mmol) in THF (3.0 mL) was treated with KOTMS (153 mg, 1.19 mmol) at room temperature. The reaction was allowed to stir 18 hours to completion, and the mixture was diluted with ether. The resulting precipitate was isolated by filtration and placed under high vacuum for two hours to afford the potassium2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate (299 mg, 118%, excess salts) as a white solid. LCMS (APCI+) m/z 282.0 [M+H]+.

後処理

  1. customThe resulting precipitate was isolated by filtration
  2. waitplaced under high vacuum for two hours

出典と根拠

ORDレコード
ord-9d5278ca5a6e469997a2954d26dfd2b7
出典データセット
uspto-grants-2011_08
特許番号
US08003651B2

反応ノート

読み込み中…