Hydrochloric Acid → 4-(Cyclopropylmethyl)-3-oxo-3,4-dihydropyrazine-2-carboxylic acid
反応式
[Li+].[OH-].[CH:3]1([CH2:6][N:7]2[CH:12]=[CH:11][N:10]=[C:9]([C:13]([O:15]C)=[O:14])[C:8]2=[O:17])[CH2:5][CH2:4]1.Cl>C1COCC1.CO>[CH:3]1([CH2:6][N:7]2[CH:12]=[CH:11][N:10]=[C:9]([C:13]([OH:15])=[O:14])[C:8]2=[O:17])[CH2:5][CH2:4]1参加物
5
実験手順
LiOH (0.84 mL, 0.84 mmol, 1.0 M) was added to a solution of methyl 4-(cyclopropylmethyl)-3-oxo-3,4-dihydropyrazine-2-carboxylate (87 mg, 0.42 mmol) in a mixture of THF-MeOH (3:1 ratio, 2 mL) at room temperature. After stirring for 2 hours, the reaction mixture was acidified to pH 1 with aq. 1N HCl solution (0.14 mL) and then concentrated to afford the desired product salt. 1H NMR (400 MHz, CD3OD) δ 7.67 (d, 1H), 7.37 (m, 1H), 3.86 (d, 2H), 1.32 (m, 1H), 0.61 (m, 2H), 0.45 (m, 2H).
後処理
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-6e31c5da0d754829971dfaf385ade190
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US08003662B2
反応ノート
読み込み中…