Methyl 2-oxopyrrolidine-3-carboxylate → 2-Oxopyrrolidine-3-carboxylic acid

HRID 1676346ノート

反応式

HRID 1676346 の反応式
[O:1]=[C:2]1[CH:6]([C:7]([O:9]C)=[O:8])[CH2:5][CH2:4][NH:3]1.C[Si](C)(C)[O-].[K+]>C1COCC1>[O:1]=[C:2]1[CH:6]([C:7]([OH:9])=[O:8])[CH2:5][CH2:4][NH:3]1

参加物

4

反応物 2

HCID 4738123Methyl 2-oxopyrrolidine-3-carboxylateHCID 23668039Potassium trimethylsilanolate

生成物 1

HCID 134743702-Oxopyrrolidine-3-carboxylic acid収率 41.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A flask was charged with methyl 2-oxopyrrolidine-3-carboxylate (500 mg, 3.49 mmol), potassium trimethylsilanolate (1344 mg, 10.48 mmol) and THF (10 mL). The reaction mixture was stirred at room temperature until the starting material had been consumed (overnight). Then HCl (20 mL, 2.0M in Et2O) was added and the mixture was stirred for 30 minutes. Then the mixture was filtered to remove the solid and the solvent was removed under reduced pressure to give the crude product (188.7 mg, 41.84%), which was used for next step without further purification.

後処理

  1. customhad been consumed (overnight)
  2. additionThen HCl (20 mL, 2.0M in Et2O) was added
  3. stirringthe mixture was stirred for 30 minutes
  4. filtrationThen the mixture was filtered
  5. customto remove the solid
  6. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-804c4a792f2445f8af8aca901c5afa6f
出典データセット
uspto-grants-2011_08
特許番号
US08003662B2

反応ノート

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