Formaldehyde → N-Cyclobutyl-1H-benzotriazole-1-methanamine
反応式
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[N:2]1.[CH:10]1([NH2:15])[CH2:14][CH2:13][CH2:12]C1.[CH2:16]=O>CCOCC>[N:1]1([CH2:16][NH:15][CH:10]2[CH2:12][CH2:13][CH2:14]2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[N:2]1参加物
5
実験手順
To a mixture of 28.6 g (0.24 mole) benzotriazole and 17.6 g (0.24 mole) of cyclopentylamine in 1000 mL of ether was added dropwise, 19.5 mL (0.24 mole) of 37% aqueous formaldehyde. The reaction mixture was stirred at room temperature under for 18 hours. The mixture was dried over calcium chloride, filtered and concentrated under reduced pressure. Hexanes was added to the residue, concentrated under reduced pressure to give the crude benzotriazol-1-ylmethyl-cyclobutyl-amine as an oil, which was used in the next without further purification.
後処理
- additionwas added dropwise
- dry with materialThe mixture was dried over calcium chloride
- filtrationfiltered
- concentrationconcentrated under reduced pressure
- additionHexanes was added to the residue
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-6c9233427cba49e189cce271d793703e
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US08003785B2
反応ノート
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