3-isopropoxy-N-(1-methyl-piperidin-4-yl)-4-nitro-benzamide → 4-amino-3-isopropoxy-N-(1-methyl-piperidin-4-yl)-benzamide

HRID 1676534ノート

反応式

HRID 1676534 の反応式
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:18]=[CH:19][C:20]=1[N+:21]([O-])=O)[C:8]([NH:10][CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:9])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[NH2:21][C:20]1[CH:19]=[CH:18][C:7]([C:8]([NH:10][CH:11]2[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]2)=[O:9])=[CH:6][C:5]=1[O:4][CH:1]([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 670764013-isopropoxy-N-(1-methyl-piperidin-4-yl)-4-nitro-benzamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 580149994-amino-3-isopropoxy-N-(1-methyl-piperidin-4-yl)-benzamide収率 95.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 1.2 g (3.6 mmole) of 3-isopropoxy-N-(1-methyl-piperidin-4-yl)-4-nitro-benzamide in 25 mL of methanol was added 0.12 g of 10% palladium on carbon. The hydrogenation reaction was carried out under 50 psi of hydrogen for 2 hours. The mixture was filtered, concentrated under reduced pressure and triturated with ether. The solid was collected by filtration, washed with ether and dried under vacuum to give 1.0 g of 4-amino-3-isopropoxy-N-(1-methyl-piperidin-4-yl)-benzamide as a white solid.

後処理

  1. customThe hydrogenation reaction
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated under reduced pressure
  4. customtriturated with ether
  5. filtrationThe solid was collected by filtration
  6. washwashed with ether
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-695d0ef61d084dc6ab4ef81caf607ec8
出典データセット
uspto-grants-2011_08
特許番号
US08003785B2

反応ノート

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