1-(Cyclopropylmethyl)piperazine → N-[2-(4-Chloro-phenyl)-ethyl]-6-(4-cyclopropylmethyl-piperazin-1-yl)-nicotinamide

HRID 1677104

反応式

HRID 1677104 の反応式
Cl[C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[O:7])=[CH:4][N:3]=1.[CH:20]1([CH2:23][N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:22][CH2:21]1>>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:5]2[CH:18]=[CH:19][C:2]([N:27]3[CH2:28][CH2:29][N:24]([CH2:23][CH:20]4[CH2:22][CH2:21]4)[CH2:25][CH2:26]3)=[N:3][CH:4]=2)=[CH:12][CH:13]=1

参加物

3

反応物 2

HCID 9658751-(Cyclopropylmethyl)piperazineHCID 80881546-chloro-N-[2-(4-chlorophenyl)ethyl]pyridine-3-carboxamide

生成物 1

HCID 57571679N-[2-(4-Chloro-phenyl)-ethyl]-6-(4-cyclopropylmethyl-piperazin-1-yl)-nicotinamide

実験手順

In analogy to example 1.a 6-chloro-N-[2-(4-chloro-phenyl)-ethyl]-nicotinamide was reacted with 1-(cyclopropylmethyl)piperazine. Off-white solid. MS (ISP): 399.3 ([M+H]+)

出典と根拠

ORDレコード
ord-bae1e122d12f4746904210ca1a24a93d
出典データセット
uspto-grants-2011_08
特許番号
US08008305B2

関連ノート

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