Trifluoroacetic acid → HCID 67215727、化合物
反応式
FC(F)(F)C(O)=O.C(O[C:13]([N:15](C)[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]([C:27]3[CH:28]=[CH:29][C:30]([N+:37]([O-:39])=[O:38])=[C:31]([CH:36]=3)[C:32]([O:34][CH3:35])=[O:33])=[O:26])=[N:23][CH:24]=2)[CH:21]=1)=O)(C)(C)C>ClCCl>[CH3:13][NH:15][C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]([C:27]3[CH:28]=[CH:29][C:30]([N+:37]([O-:39])=[O:38])=[C:31]([CH:36]=3)[C:32]([O:34][CH3:35])=[O:33])=[O:26])=[N:23][CH:24]=2)[CH:21]=1参加物
4
実験手順
1.3 ml of trifluoroacetic acid are added to 460 mg (1.01 mmol) of methyl 5-({6-[(tert-butoxycarbonyl)(methyl)amino]imidazo[1,5-a]pyridin-3-yl}carbonyl)-2-nitrobenzoate in 5 ml of dichloromethane and the mixture is stirred at ambient temperature overnight. The reaction medium is concentrated under reduced pressure. The residue is taken up in water and basified with a saturated aqueous sodium bicarbonate solution and then extracted with dichloromethane. The organic phase is washed with a saturated aqueous sodium chloride solution, then dried over sodium sulfate and concentrated under reduced pressure. 350 mg of a red powder are obtained. Melting point: 183° C.; 1H NMR (d6-DMSO): 2.79 (3H, d), 3.90 (3H, s), 7.11 (1H, d), 7.77 (1H, s), 7.82 (1H, d), 8.31 (1H, d), 8.66 (1H, d), 8.75 (1H, s), 9.01 (1H, s)