HCID 67376231、化合物 → HCID 86608784、化合物

HRID 1677599ノート

反応式

HRID 1677599 の反応式
[CH2:1]([O:3][C:4](=[O:24])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])=[CH:9][CH:8]=1)=[CH2:6])[CH3:2].[C:25]([OH:28])(=[S:27])[CH3:26]>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:24])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])=[CH:9][CH:8]=1)[CH2:6][S:27][C:25](=[O:28])[CH3:26])[CH3:2]

参加物

4

反応物 2

HCID 67376231HCID 67376231、化合物HCID 178418634HCID 178418634、化合物

生成物 1

HCID 86608784HCID 86608784、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of 2-(4-(benzyloxycarbonylamino)phenyl)prop-2-enoic acid ethyl ester (2.2 g, 7.55 mmol) and thioacetic acid (5 mL) in 10 mL of chloroform was heated for 18 hours. The reaction mixture was evaporated in vacuo and purified by flash chromatography through silica gel (5/1 hexanes/ethyl acetate) to afford 2-(4-(benzyloxycarbonylamino)phenyl)-3-(acetylthio)propanoic acid ethyl ester, 0.22 g (8%) as an oil.

後処理

  1. customThe reaction mixture was evaporated in vacuo
  2. custompurified by flash chromatography through silica gel (5/1 hexanes/ethyl acetate)

出典と根拠

ORDレコード
ord-2b46806bd7134be0b9026e8d95101191
出典データセット
uspto-grants-2011_08
特許番号
US08008325B2

反応ノート

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