4-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile → HCID 16749887、化合物

HRID 1677654

反応式

HRID 1677654 の反応式
[CH:1]1[N:5]=[CH:4][N:3]2[CH2:6][CH:7]=[C:8]([C:9]3[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=3)[C:2]=12>CO.[Pd]>[CH:1]1[N:5]=[CH:4][N:3]2[CH2:6][CH2:7][CH:8]([C:9]3[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=3)[C:2]=12

参加物

4

反応物 1

HCID 669338694-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile

生成物 1

HCID 16749887HCID 16749887、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 0.99 mmol of 4-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile in 15 ml of MeOH is hydrogenated in the presence of 123 mg of 10% Pd/C at room temperature for 5.5 hours. The reaction mixture is subjected to clarifying filtration and the filtrate is evaporated. From the residue the title compound is obtained by means of flash chromatography (SiO2 60F) as a-pale reddish solid. Rf=0.22 (dichloromethane/ammonia (2M in EtOH) 97:3), Rt=4.43 (Gradient I).

後処理

  1. filtrationfiltration
  2. customthe filtrate is evaporated

出典と根拠

ORDレコード
ord-00dad5054bce4742a03a1d72cf2f63cb
出典データセット
uspto-grants-2011_08
特許番号
US08008334B2

関連ノート

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