Ammonium Chloride → 4-Amino-7-(trifluoromethyl)quinoline

HRID 1678308

反応式

HRID 1678308 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[Cl-].[NH4+:17]>CO>[NH2:17][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 25517Ammonium ChlorideHCID 676684-Chloro-7-(trifluoromethyl)quinoline

生成物 1

HCID 27359604-Amino-7-(trifluoromethyl)quinoline

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 4-chloro-7-trifluoromethylquinoline (1 g) and ammonium chloride (1 g) in methanol (10 mL) was heated at 70° C. overnight. Then the solid was filtered off and washed with methanol. The filtrated was evaporated to give 4-amino-7-trifluoromethylquinoline. LCMS: ret. time: 14.81 min.; purity: 82.25%; MS (m/e): 228.11 (M+16).

後処理

  1. filtrationThen the solid was filtered off
  2. washwashed with methanol
  3. customThe filtrated was evaporated

出典と根拠

ORDレコード
ord-2299b1780c344cf68e6af34e073ce4f6
出典データセット
uspto-grants-2011_08
特許番号
US08008501B2

関連ノート

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