Water → 3-(4-Methyl-1H-imidazol-1-YL)-5-(trifluoromethyl)benzonitrile

HRID 1678348ノート

反応式

HRID 1678348 の反応式
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.[H-].[Na+].F[C:10]1[CH:11]=[C:12]([CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1)[C:13]#[N:14].O>CN1CCCC1=O>[CH3:1][C:2]1[N:3]=[CH:4][N:5]([C:10]2[CH:17]=[C:16]([C:18]([F:19])([F:21])[F:20])[CH:15]=[C:12]([CH:11]=2)[C:13]#[N:14])[CH:6]=1

参加物

6

反応物 4

HCID 962WaterHCID 24758Sodium hydrideHCID 5190373-Fluoro-5-(trifluoromethyl)benzonitrileHCID 178418800HCID 178418800、化合物

生成物 1

HCID 469003933-(4-Methyl-1H-imidazol-1-YL)-5-(trifluoromethyl)benzonitrile

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒3 回

反応条件

温度
22.5 °C

実験手順

A solution of 4-methyl-1H-imidazole (1.98 g, 24.11 mmol) in N-methylpyrrolidinone (NMP) (18 mL) is added to a solution of sodium hydride (0.82 g, 60%, 20.5 mmol) in NMP (18 mL) at 20-25° C. under an atmosphere of nitrogen. The mixture is stirred for 1 hour, before a solution of 3-fluoro-5-trifluoromethyl benzonitrile (XXI) (3.2 g, 16.4 mmol) in NMP (8 mL) is added. The reaction mixture is stirred for 2 hours at 20-25° C. and then water (120 mL) is added within 20 minutes and the resulting suspension is stirred for 16 hours.

後処理

  1. additionis added
  2. stirringthe resulting suspension is stirred for 16 hours

出典と根拠

ORDレコード
ord-f70f3809d61242f0a8903fadbc8f246e
出典データセット
uspto-grants-2011_08
特許番号
US08008504B2

反応ノート

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