Sodium Hydroxide → 1-[4-chloro-6-(methylamino)-1,3,5-triazin-2-yl]-N-{[-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

HRID 1678411ノート

反応式

HRID 1678411 の反応式
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][NH:10][C:11]([CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[O:12].[Cl:21][C:22]1[N:27]=[C:26](Cl)[N:25]=[C:24]([NH:29][CH3:30])[N:23]=1.[OH-].[Na+]>>[Cl:21][C:22]1[N:23]=[C:24]([NH:29][CH3:30])[N:25]=[C:26]([N:16]2[CH2:17][CH2:18][CH:13]([C:11]([NH:10][CH2:9][C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[C:2]([F:1])([F:19])[F:20])=[O:12])[CH2:14][CH2:15]2)[N:27]=1

参加物

4

反応物 3

HCID 14798Sodium HydroxideHCID 3122014,6-dichloro-N-methyl-1,3,5-triazin-2-amineHCID 59614575N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

生成物 1

HCID 866443121-[4-chloro-6-(methylamino)-1,3,5-triazin-2-yl]-N-{[-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

反応条件

温度
40 °C

実験手順

N-{[2-(Trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide (464 mg, 1.63 mmol, 1.00 equiv) was added to the suspension prepared in step b. The resulting mixture was heated to 40° C. and treated with 1 N NaOH to maintain a pH of 9-10. The reaction mixture was stirred for 2 h and then used immediately in the next step without workup or purification. MS (ES+): m/e 428.9 [M+H]+.

後処理

  1. temperatureto maintain a pH of 9-10
  2. customused immediately in the next step without workup or purification

出典と根拠

ORDレコード
ord-35ca18e7b8e34ebdb2631e01f38b11be
出典データセット
uspto-grants-2011_08
特許番号
US08008483B2

反応ノート

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