Cesium carbonate → 5'-Methoxycarbonyl-2'-methylbiphenyl-4-carboxylic acid

反応式

[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[C:6](Br)[CH:5]=1.[OH:13][C:14]([C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][CH:17]=1)=[O:15].C(=O)([O-])[O-].[Cs+].[Cs+]>COCCOC>[CH3:1][O:2][C:3]([C:4]1[CH:5]=[C:6]([C:19]2[CH:20]=[CH:21][C:16]([C:14]([OH:15])=[O:13])=[CH:17][CH:18]=2)[C:7]([CH3:10])=[CH:8][CH:9]=1)=[O:12]

参加物

実験手順

A mixture of 3-bromo-4-methyl-benzoic acid methyl ester (3 g), 4-hydroxycarbonyl-phenyl boronic acid (2.21 g), cesium carbonate (4.26 g) and tetrakis(triphenylphosphine)palladium0 (catalytic quantity), in 1:2 aqueous DME (75 ml) was heated to reflux for 18 h. The cooled reaction was then evaporated to dryness and the residue purified on silica gel. Elution with dichloromethane:ethanol:0.880 ammonia; 800:8:1 to 100:8:1 gave a yellow crystalline solid (3.4 g)