Sodium Hydroxide → 4-[5-(Tert-butoxycarbonylamino)-2-methyl-phenyl]benzoic acid

HRID 1678463ノート

反応式

HRID 1678463 の反応式
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH:15]=[CH:14][C:13]=2[CH3:26])=[CH:8][CH:7]=1)=[O:5])C.[OH-].[Na+]>C(O)C>[C:22]([O:21][C:19]([NH:18][C:16]1[CH:15]=[CH:14][C:13]([CH3:26])=[C:12]([C:9]2[CH:8]=[CH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:11][CH:10]=2)[CH:17]=1)=[O:20])([CH3:25])([CH3:24])[CH3:23]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 598223705'-tert-Butoxycarbonylamino-2'-methyl-biphenyl-4-carboxylic acid ethyl ester

生成物 1

HCID 598223484-[5-(Tert-butoxycarbonylamino)-2-methyl-phenyl]benzoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5′-tert-Butoxycarbonylamino-2′-methyl-biphenyl-4-carboxylic acid ethyl ester (6.3 g) was stirred in ethanol (75 ml) and 1M sodium hydroxide (30 ml) at 20 C for 18 h. The mixture was then acidified and the ethanol evaporated. The pale beige solid thus formed was collected by filtration and dried (4.26 g)

後処理

  1. customthe ethanol evaporated
  2. customThe pale beige solid thus formed
  3. filtrationwas collected by filtration
  4. customdried (4.26 g)

出典と根拠

ORDレコード
ord-b7aedf9efb6847d9a24fb4e5dd7c8d98
出典データセット
uspto-grants-2011_08
特許番号
US08008303B2

反応ノート

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