5'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid ethyl ester → 5'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid

HRID 1678518ノート

反応式

HRID 1678518 の反応式
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18][C:19](=[O:30])[CH2:20][N:21]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH3:22])[CH:15]=[CH:14][C:13]=2[Cl:31])=[CH:8][CH:7]=1)=[O:5])C>[OH-].[Na+].C(O)C>[C:26]([O:25][C:23]([N:21]([CH3:22])[CH2:20][C:19]([NH:18][C:16]1[CH:15]=[CH:14][C:13]([Cl:31])=[C:12]([C:9]2[CH:8]=[CH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:11][CH:10]=2)[CH:17]=1)=[O:30])=[O:24])([CH3:29])([CH3:28])[CH3:27]

参加物

4

反応物 1

HCID 673712285'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid ethyl ester

生成物 1

HCID 673744955'-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2'-chloro-biphenyl-4-carboxylic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

5′-[2-(tert-Butoxycarbonyl-methyl-amino)-acetylamino]-2′-chloro-biphenyl-4-carboxylic acid ethyl ester (494 mg) in 2M NaOH (10 ml) and ethanol (15 ml) was stirred at room temp for 18 h. The ethanol was then evaporated and the residue acidified with HCl. The colourless solid formed was collected by filtration and dried (420 mg).

後処理

  1. customThe ethanol was then evaporated
  2. customThe colourless solid formed
  3. filtrationwas collected by filtration
  4. customdried (420 mg)

出典と根拠

ORDレコード
ord-d8a6323c848a497ea91c5dbaaef6b134
出典データセット
uspto-grants-2011_08
特許番号
US08008303B2

反応ノート

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