1,2-Dimethoxyethane → 2'-Methoxy-5'-(2-methyl-4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid

HRID 1678529ノート

反応式

HRID 1678529 の反応式
Br[C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:10][C:9]=1[CH3:20])=[O:6].C([O:28][C:29]([C:31]1[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=1)=[O:30])C.COCCOC.C(=O)([O-])[O-].[Cs+].[Cs+]>O>[CH3:25][O:24][C:23]1[CH:22]=[CH:21][C:4]([C:5](=[O:6])[NH:7][C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)=[CH:10][C:9]=2[CH3:20])=[CH:3][C:2]=1[C:34]1[CH:35]=[CH:36][C:31]([C:29]([OH:30])=[O:28])=[CH:32][CH:33]=1

参加物

6

反応物 4

HCID 80711,2-DimethoxyethaneHCID 10796Cesium carbonateHCID 27343504-Ethoxycarbonylphenylboronic acidHCID 673739843-Bromo-4-methoxy-N-(2-methyl-4-morpholin-4-yl-phenyl)-benzamide

生成物 1

HCID 673743492'-Methoxy-5'-(2-methyl-4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 3-Bromo-4-methoxy-N-(2-methyl-4-morpholin-4-yl-phenyl)-benzamide (432 mg) and 4-(ethoxycarbonyl)-phenyl boronic acid (311 mg) in 2:1 DME:water (15 ml) containing cesium carbonate (697 mg) and tetrakis(triphenylphosphine)palladium0 (127 mg) was heated to reflux for 18 h.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 18 h.

出典と根拠

ORDレコード
ord-96690057a1ce48d18410318896f3af9d
出典データセット
uspto-grants-2011_08
特許番号
US08008303B2

反応ノート

読み込み中…